Am I Going To Develop Antibiotic Resistance From Taking Doxycycline?

Am I Going To Develop Antibiotic Resistance From Taking Doxycycline?

November 11, 2018

Am I going to develop antibiotic resistance from taking long term low dose doxycycline for gum disease?This is perhaps the question I have been asked more in the last 20 plus years than any other question. The following excerpts have been taken from the abstract of a research paper by Roberta DiCaprio, Serena Lembo, Luisa Di Costanzo, Anna Balato and Giuseppe Monfrecola titled – Anti-Inflammatory Properties of Low and High Doxycyline Doses: An in Vivo Study.

“Doxycycline is used to treat infective diseases because of its broadspectrum efficacy. High dose administration (100 or 200 mg/day) is often responsible for development of bacterial resistances and endogenous flora alterations, whereas low doses (20–40 mg/day) do not alter bacteria susceptibility to antibiotics and exert anti-inflammatory activities.”

“The nonantibiotic anti-inflammatory effects of tetracyclines are under investigation for the treatment of multiple diseases. Their efficacy has already been reported in rheumatoid arthritis, corneal inflammation, gingivitis, osteoarthritic cartilage, allergen-induced inflammation, and a lot of other conditions like cardiovascular, neurological, and skin disorders. The wide spectrum of anti-inflammatory effects ascribed to tetracyclines is probably due to their ability to interfere with the synthesis or activity of several mediators of inflammation.” In addition, tetracyclines inhibit metalloproteinases (MMPs) and suppress hydrolases such as α-amylases and phospholipase A2 (key enzyme in the biosynthesis of inflammatory mediators such as the prostaglandins (PGE).”

So what does all that mumbo jumbo mean? It means that doxycycline in low dose suppresses the enzymes that destroy the attachment of gum and bone to teeth and lead to bone loss and recession. Additionally, low dose doxycycline suppresses inflammation which causes the gums to pink up and lose their red inflamed puffy appearance. Best of all, low doses of doxycycline does not lead to antibiotic resistance.

Article written by Dr. Adrian Pawlowski DDS, MSD, board certified member of the American Academy of Periodontics.

Bell Harbour Dental is a family owned, patient-first practice located in Belltown, Downtown Seattle. Check us on out Facebook, Google+ and Instagram, or contact us today to boost your dental health today!

©2024 Bell Harbour Dental | Privacy Policy | Web Design, Digital Marketing & SEO By Adit